com.bea.wli.sb.transports.TransportException: Failed to create JCABindingReference for wsdl: servicebus:/MYINTGR_01/Resources/resources/application_24/inbound_25/resourcegroup_26/invoke1_REQUEST.wsdl, operation: invoke1_REQUEST, exception: BINDING.JCA-12600 Generic error. JCA binding runtime error. Cause: {0}.
Turned out, the Connectivity (or On-Premise) Agent on the on-premise DB crashed and the ICS couldn't fetch metadata for creating the web service.
Contact your admin to restart the agent.